β-glucan from Lentinus edodes inhibits breast cancer progression via the Nur77/HIF-1α axis
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چکیده
منابع مشابه
Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism
β-Glucans are well known for its various bioactivities, but the underlying mechanism has not been fully understood. This study focuses on the anti-tumor effect and the potential mechanism of a branched β-(1, 3)-glucan (LNT) extracted from Lentinus edodes. The in vivo data indicated that LNT showed a profound inhibition ratio of ~75% against S-180 tumor growth, even significantly higher than the...
متن کاملThe β-glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers
Breast cancer is now the most common cancer in worldwide women, and novel interventions are needed to overcome the resistance occurring in the estrogen-targeted endocrine therapy. Herein, we demonstrate that the β-glucan from Lentinus edodes (LNT) exhibited a profound inhibition ratio of ∼53% against estrogen receptor positive (ER+) MCF-7 tumor growth in nude mice similar to the positive contro...
متن کاملShiitake (Lentinus edodes)
Shiitake mushroom, the common Japanese name for Lentinus edodes (Fig. 1), derives from the mushroom associated with the shii tree (Castanopsis cuspidate Schottky) and take, the Japanese word for mushroom (Table 1). Because Japan is the world leader in production of this type of mushroom, the mushroom is now widely known by this name. These mushrooms are renowned in Far East countries (e.g., Jap...
متن کاملPolysaccharide from Lentinus edodes Inhibits the Immunosuppressive Function of Myeloid-Derived Suppressor Cells
Reversing the function of immune suppressor cells may improve the efficacy of cancer therapy. Here, we have isolated a novel polysaccharide MPSSS (577.2 Kd) from Lentinus edodes and examined its effects on differentiation and function of myeloid-derived suppressor cells (MDSCs). MPSSS is composed of glucose (75.0%), galactose (11.7%), mannose (7.8%), and xylose (0.4%). In vivo, it inhibits the ...
متن کاملLentinus edodes the 2 nd 5 ' - Nucleotide - forming Nuclease from
28, 36, and 41 kDa, On the other hand, Kurosawa et al.4) found an alkaline RNase in addition to three acid nucleases in frcsh fruit bodies of L, edodes confirming the results of Endo et aLi) To establish more precise information on these enzymes, we tried to isolate and characterize each nuclease or RNase in L. edodes. First, we isolated an acid RNase, RNase Le2, and established the prirnary st...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2020
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20201006